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Cases of the black death in Europe were first seen in 1347 Messina, Italy, it spread through Europe killing millions, but it didn't actually started here
The disease spread easily once in the cities as the living conditions of the cities in Europe were of a very low standard. They didn't know much about hygiene as they chucked all their waste on the street. YUCK!
Trade was a big part of Europe they traded on land as well as by sea. This was a big part on helping the spread of the plague, as the boats could travel from one country to another with out any quarantine.
The plague appears to have been brought to the Middle East from warriors returning from Iran. They brought the disease with them back home. The food that the warriors carried were infested with the disease and rats.
This grain, that was their food was carried throughout the Middle East infecting towns as they past, spreading the black death unknowingly. They passed Iraq, Syria, and southern Turkey. Which were all soon infected with the Black Death.
Muslim pilgrims coming from northern India going to Mecca via the Persian Gulf and the Red Sea, were likely to be transporting diseased rats from Central Asia to the Arabian Peninsula. Spreading the plague even further.
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