Neurotransmission Part 2
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- Okayyyyyy psychos! Today we're talking about neurotransmission.
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- Some more definitions:"action potential" (a.c.) - signal that travels as an electrical impulse in the brain"antagonist" - have a blocking effect, usually post-synaptically"agonist" - have an activating effect, usually pre-synaptically"inhibitory" - decreases a.c."excitatory" - increases a.c."endrogenous" - naturally occuring"exogenous" - artificially made, administered as a drug
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- Going back to noradrenaline, the 1986 study by Smith Nutt we discussed last time had two exogenous neurotransmitters. Remember them?Clonidine, an agonist, works on the presynaptic neuron. It activates the receptors, which lowers noradrenaline.Meanwhile, idazoxan, an antagonist, also works on the pre-synaptic neuron, but it blocks the receptors, thus increasing noradrenaline.The way these two neurotransmitters work is what allowed Smith and Nutt to come to the conclusion that the central noradrenaline level is important to maintaining attention.For next time - please come up with a creative way to present how noradrenaline works.That's all for today psychos!
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