An enzyme called Primase starts the process of replication. This enzyme makes a small piece of RNA called a primer
DNA Ligase
Primase
Helicase
Lagging
Leading
Next, 2 enzymes called DNA polymerase I and III bind to the primer. The main function of this enzyme is a duplication of the chromosomal DNA. DNA polymerase I add in the 3’ to 5’ direction (Leading strand) and DNA polymerase III adds to the 5’ to 3’ direction (Lagging strand)
DNA Pol. I
Primase
3'
5'
The lagging strand is placed in chunks called Okazaki fragments. After all the DNA is made DNA polymerase I removes all the RNA primers from both strands of DNA
DNA Pol. I
Primase
5'
3'
DNA ligase seals up the fragments of DNA in both strands to form a continuous double strand. Lastly, an enzyme called exonucleases proofreads the remaining DNA and DNA polymerase I repairs any errors.
WOW THATS AMAZING
DNA Ligase
IM READY
And there Kyle is DNA replication. Ready to go back?
DNA Replication
Its was great help Mr. Rims. I have a great understanding of the enzymes used, steps and bases of DNA replication!!!
I'm glad that demonstration helped Kyle. You better get home and start studying for the test
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