Charlie Gordon a 32 year old is a disabled man and is chosen for an experiment surgery to increase his intelligence. The procedure already worked on a mouse called Algernon, and the doctors are hopeful and confident that it will be successful with Charlie, too.
The surgery is successful, and Charlies intelligence becomes great. However, he finds that he cant keep up with his mental understanding. He realizes that he has been treated cruelly by his ¨friends¨ at the bakery, and others throughout life.
Charlie got fired from his job at the bakery . The others treat him strangely now, and with fear. They dont understand the change that is happening in Charlie. Charlie learns so much information that he quickly exceeds his doctors. He develops a sense of like-mindedness with Algernon, and feels set apart from the people he interacts with, including Miss Kinian.
Charlie is taken to a scientific convention in Chicago where he and Algernon are being showcased. Charlie becomes increasingly anxious as they show films and pictures of him in early interviews, which he had not been aware of. He and Algernon go back to New York. Algernon soon begins to return back to his less developed state, and Charlie realizes that he doesnt have much time left.
Charlie and Algernon return to the lab, where Charlie continues his research. He ends his relationship with Miss Kinian. Algernon dies, and Charlie goes to visit his mother. He finds his mother is senile.
Charlie and Mrs. Kinian make a relationship before Charlies regressions worsens. They spend a few weeks together before Charlies moods drive her away. His coordination, spelling, and grammar worsen. His final wish as he finishes his last progress report before going to live at the Warren Home is for someone to put flowers in Algernons grave.