The story takes place primarily in the Town of Dooling and is told through the perspective of multiple characters with slight connections between each one.
One day, a girl named Evie appears near the outskirts of the town. She kills two men staying in a mobile home but spares the girl, she is sent to prison.
After Evie's arrival, a "disease" begins spreading throughout the world that only effects women. If a women falls asleep, a cocoon will begin covering their body and they will enter a permanent state of unconsciousness. Obviously, this sends the world into utter chaos.
After the surge in women falling into this comma like state, many men began trying to pry off the cocoon. This led to the women awakening with a great amount of fury with a mission to slaughter the one that woke them and then fall back into their slumber.
As it turns out, when women in the Town of Dooling fall asleep, their mind transfer them into an alternate world in which no men exist. This world was created by Evie in order to give women a chance to rebuild a once corrupt society. The women of Dooling were then faced with the challenge of choosing between their families from the old world, or continuing with their peaceful life in the alternate world.