When White and Company arrived at Roanoke Island they found the fort demolished, the island deserted, and only the bones of one man was found from the unsuccessful attempt 2 years earlier.
John White's daughter, Elinor, and her husband, Ananias Dare, were one of the 117 colonists that White had brought over to the New World. They were expecting a baby. And less than a month from when they arrived, their daughter, Virginia, was born. She was the first child born in the New World. John White went back to England to get supplies, a trip that was supposed to take 4-6 months but took 3 years to get back to the colony.
The most likely scenario that happened was the theory that the colonists relocated to Croatoan Island. Evidence to support this theory is that the word "CROATOAN" and the letters "CRO" were found on trees. The colonists were told to write the name of the location they were going to and a cross underneath if they were in danger, no cross was found at the trees. Also, European items were found at Croatoan Island, like a ring belonging to one of the colonists, lead bullets, brass buttons, and pots and pans. Also, European skeletons were found on Croatoan Island along with Native American bones.