Setting: The narrator visited his childhood friend, Roderick Usher, at an old, decaying mansion far out in a desolate countryside with decaying trees and murky ponds around it.
Roderick reveals to the narrator that he is physically and mentally ill and his twin sister, Madeline, has taken ill with a mysterious disease. Shortly after, she passes and Usher decides to bury her under the house. Usher's appearance and demeanor worsen after her death.
Shortly after Madeline's death, the narrator begins to hear strange noises in the house. One night, Roderick wakes the narrator up, hysterical about the terrifying atmosphere of fog outside. The narrator begins to read to Usher to calm him down.
As the narrator reads, he hears noises that correspond to the story. Then, they hear a scream. Roderick begins rocking back and forth, whispering that he's been hearing his sister and fears that he might've buried her alive. Then, the door flies open and there is Madeline, covered in blood.
Madeline attacks Roderick, causing him to die out of fear. Then, Madeline dies as well. The narrator flees the house as a result.
As the narrator watches, the house crumbles down before him and is eventually gone.