Spain went through many inquisitor generals. Under the administration of Inquisitor General Torquemada, torture became an essential part in getting confessions. It wasn't until he investigated some clergymen that Pope Alexander the Sixth decided to keep him in check by forcing him to share his leadership with four others. After him, Diego de Deza, who accepted bribes, took over, and then it was Cardinal Gonzalo Ximenes Cisneros, who relentlessly pursued the Muslims, even down into Northern Africa, before being dismissed from his duties in 1517.
Confessed heretics were sentenced publicly in an event called the Auto-da-Fe (act of faith). Those who wouldn't confess were burned at the stake.
On March 31, 1492, Ferdinand and Isabella issued an edict giving Spanish Jews the choice of either leaving or facing death. More than 160,000 Jews were expelled from Spain as a result.