10 people, Emily Brent, Anthony Marston, Vera Claythorne, Mr. and Mrs. Rogers, Justice Wargrave, Phillip Lombard, Inspector Blore, General Macarthur, and Dr. Armstrong are all mysteriously invited to an island by an unknown person. Soon one by one, they all die like the nursery rhyme in their rooms.
The characters want to find out who put them on the island and who is murdering them.
But, the characters can't find a motive or an opportunity for any of the other people, and almost all of them have an alibi. But soon there are only two people on the island, Lombard, and Vera.
Vera shoots Lombard, thinking he is the killer, and then hangs herself. In the end, we read a letter saying that Justice Wargrave was actually the killer and he was the one who collected all those people and killed them by faking his own death.