In 1492, Christopher Columbus was in search of the water route to Asia. Columbus accidentally ended up in America. He mistook America for Asia. He did not find the water route to Asia, but he was the first to discover the new world.
In 1519, Pineda thought he could be famous by proving the Atlantic,and Pacific oceans connected. But he failed.
In 1521, Cortes and his army reached tenochtitlan.
In 1527, Cabeza de Vaca went on an expedition too find gold. When he failed, he lied to Spain and told them there was a Seven Cites of Gold.
In 1540, Coronado led a group of men the Seven Cities of Gold. (Which De Vaca described.)
In 1516, La Salle calimed part of Canada for France.