Upon finding the New World, English settlers colonize a island known as Roanoke. They start by placing a few settlers to begin colonization.
Somewhere along the line, the colonist have a hostile encounter with some Native Americans, wiping out the entire colony.
When reaching the colony after 3 years of absence, John White and his crew find a completely empty colony. The only hint of what might have happened was the word, "Croatoan" on the gatepost. This is what I theorize caused the end of the colony.