If San Francisco is populated by many competent and foreign people it's thanks to Abstergo. They use a strange thing named "the Observatory". This allows them to know where anyone is on earth and then to kidnap those who Abstergo is most interested by them for his society.
The Apple of Eden is an ancient artefact able to know someone's abilities, read their minds or take control of an individual and make him do whatever we want and can do much stranger things. It's thanks to this mysterious object that Abstergo identify the smartest people into the world to work for them and also to find out who are the people of San Francisco who are not useful to the society (bad students, unemployeds, thiefs …).
All the people not serving the society of Abstergo are sent to the old prison of Alcatraz, redeveloped into a labyrinth containing a terrifying mythological monster and having come to life thnaks to the Apple of Eden.