King Philip II of Spain, a Catholic, fought Protestants throughout Europe because of his belief in his divine right.
Queen Elizabeth I of England, a Protestant, fought back against Philip's advances despite his possession of what was thought to be the strongest navy in Europe.
King Philip never had good relations with Queen Elizabeth. Among other things, she rejected his marriage proposal, but Phillip ended up attacking because England was a Protestant nation and Spain was a Catholic nation, and the Spaniards felt that that was wrong.
The Spanish Armada lost due to a multitude of complications, such as unforgiving winds and weather, unpreparedness for modern English artillary, and a flawed plan of attack
The war between England and Spain led to the loss of nearly half of the Spanish Armada, weakening the Spaniards for many years to come.