Spain wanted to colonize the aztecs because they wanted the material aid and mineral wealth from the colony, and felt obligated to spread Christianity to the natives.
The Spanish introduced the Aztecs to domestic animals, sugar, grains, and European farming practices.
Spanish conquistadors worked with local tribes to attack the aztec capital Tenochtitlán and a combination of superior weaponry and a devastating smallpox outbreak enabled the Spanish to conquer the city.
Between 1519 and 1521 Hernán Cortés and a small band of men brought down the Aztec empire in Mexico
The advantages that the Spanish had over the Aztecs were 16 horses, guns, armor, formed alliances, diseases, and steel.
The Spanish had a negative rule that effected the aztecs. The surviving Aztecs were highly susceptible to European diseases previously unknown to their culture, such as smallpox and typhus.