Kino, Juana, and Coyotito live peacefully in Le Paz, Mexico. They live a poor but happy lifestyle.
Coyotito gets bit by a scorpion while in his crib, and Juana attempts to suck the poison out. She asks for the doctor but knows he wont come, so they go to the city in seach of him. However he refuses to treat Coyotitio.
After the doctor refuses to treat Coyotito, Kino takes his canoe and goes to look for the pearl of the sea, and he finds it. However, now Coyotitio is miraculously healed.
The pearl has changed the town for the worse and Kino gets attacked multiple times. On one of the times he is attacked, he kills a man out of self defense. His house is burned down and all hope is lost. They go on the run.
Kino, Juana, and Coyotitio are on the run from the trackers. Kino plans to kill the trackers but Coyotito cries and he gets shot and dies. Kino kills all three men and is ashamed of who he has become.
KIno and Juana walk back to Le Paz and the whole town notices their differences now. They are more distant and seem cut off from human interaction. Kino takes the pearl and returns it back to the sea, only hearing the sound of evil emanating from it now.