Victor Frankenstein travels to the north pole tracking his creature. This mission shows the lengths Victor will go to get revenge on the creature. He suffers from the cold and almost dies just to get his revenge.
Frankenstein brings his creature to life, he then rejects it because he can't bear to look at his creation without disgust. He eventually leaves the creature to die and tries to live on without the creature. This is the punishment for Victor's quest for knowledge.
The creature stalks the DeLaceys for a very long time, eventually, Safie gets there. The creature then shows himself and gets rejected by the entire family. He then starts to hate humanity. This is when the creature realizes that he is and always will be isolated from humanity.