Another important thing is the airlift reactor requires only a low energy for homogenous mixture and shear force! Since the cells used will be shear-sensitive cells, you may consider airlift reactor too!
I see! Let us think for a while ya! We'll list out the applications of those bioreactors and we'll come back to you with a decision.
Alright, no problem!
Hello. Are you the engineer?
We come here to fulfill our mission. A new vaccine is coming. But first, tell us about your bioreactors.
Hi. Yes, yes! So, you are the scientist I heard about! How can I help you?
Ah, a new vaccine! That's amazing! Well well we have 3 different types of bioreactors. Please follow me.
In the bioreactor room..
Oh yes! This is very popular in industrial bioprocess for both microbial and enzymatic.
But the problem is, our cells are shear-sensitive. I'm afraid it will be destroyed by the impeller at high stirrer speed.
Oh my! It is true, extra care is required for those cells. But no worries! We have another 2 types of bioreactors that may fit to your needs!
Exactly! It is incorporated with impellers for chemical agitation and gas dispersion. Therefore, the broth concentration will be homogenous.
So this is a stirred-tank bioreactor.
Hmm, if there is no impellers and no moving parts, how will it ensure a homogenous mixture?
Now, this is the bubble column bioreactor. It is simple to construct as well as operate. No moving parts, suitable for your shear-sensitive cells.
That's the magic! Compressed air is injected into the base of a cylindrical vessel, and it is used for agitation as well as the oxygen supply for your culture.
Oh! Plus the turbulence distributed more evenly in this tank.
Alright ! This is the airlift reactor. It is a typical motionless bioreactor where the internal circulation and mixing are achieved by bubbling air.
The mixing can be done as this reactor consists of 2 liquid steams, upflowing and downflowing steams. The liquid circulates in the reactor as a result of the density difference, providing a uniform flow.