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  • Hello. Are you the engineer?
  • We come here to fulfill our mission. A new vaccine is coming. But first, tell us about your bioreactors.
  • Hi. Yes, yes! So, you are the scientist I heard about! How can I help you?
  • Ah, a new vaccine! That's amazing! Well, well we have 3 different types of bioreactors. Please follow me.
  • In the bioreactor room..
  • Oh yes! This is very popular in industrial bioprocess for both microbial and enzymatic.
  • But the problem is, our cells are shear-sensitive. I'm afraid it will be destroyed by the impeller at high stirrer speed.
  • Oh my! It is true, extra care is required for those cells. But no worries! We have another 2 types of bioreactors that may fit to your needs!
  • Exactly! It is incorporated with impellers for chemical agitation and gas dispersion. Therefore, the broth concentration will be homogenous.
  • So this is a stirred-tank bioreactor.
  • Hmm, if there is no impellers and no moving parts, how will it ensure a homogenous mixture?
  • That's the magic! Compressed air is injected into the base of a cylindrical vessel, and it is used for agitation as well as the oxygen supply for your culture.
  • Oh! Plus the turbulence distributed more evenly in this tank.
  • Now, this is the bubble column bioreactor. It is simple to construct as well as operate. No moving parts, suitable for your shear-sensitive cells.
  • Alright ! This is the airlift reactor. It is a typical motionless bioreactor where the internal circulation and mixing are achieved by bubbling air.
  • The mixing can be done as this reactor consists of 2 liquid steams, upflowing and downflowing steams. The liquid circulates in the reactor as a result of the density difference, providing a uniform flow.
  • Well, how does this bioreactor works ?
  • Another important thing is the airlift reactor requires only a low energy for homogenous mixture and shear force! Since the cells used will be shear-sensitive cells, you may consider airlift reactor too! 
  • I see! Let us think for a while ya! We'll list out the applications of those bioreactors and we'll come back to you with a decision. 
  • Alright, no problem!
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