"An whatta I got, I got you! You can't keep a job and lose me every job I get."
Character vs. Character
"By Christ, he's gotta talk when he's spoken to. What the hell are you gettin' into it for?
Character vs. Society
"I turns to Lennie and says "Jump in." An he jumps. Couldn't swim a stroke."
George needs a job desperately; however, he also needs to take care of Lennie. He is stuck between doing well on a job and protecting Lennie. George is frustrated of getting a good job that also allows him to protect Lennie from his problems.
George and Curly have problems with each other because George wants to protect Lennie from any harm and Curley doesn't like big tall guys and wants to feel superior by letting people know he is the son of their boss.
Lennie is very innocent and not very bright, so it would be a problem for him to fit in with society. He does not understand situations most people do. Lennie takes an action without taking in the consequences,this would interpret him as different and unlike.