Macbeth (after experiencing the prophecy become reality) is paranoid that Banquo's son, Fleance, will become king so he sends 2 henchmen to ambush the two on their way to a feast. Banquo is killed but Fleance escapes.
The henchmen return to the castle for the feast, informing Macbeth of the escape. This made him more paranoid, and resulted in him hallucinating about Banquos ghost in front of the guests of the feast, making them see his guilt.
The next day, Macbeth visits the witches out of fear and has a hallucination telling him that he has to beware of Macduff, he can't be hurt by anyone of woman born, and he is safe until Birnam Wood comes to Dunsinane Castle.
Macduff flees to England and joins Malcom in raising a large army to destroy the corrupt Macbeth. In return, Macbeth kills Macduff's wife and children.
During all of these events, Lady Macbeth was slowly becoming crazy as she hallucinated there was blood on her hands because of her manipulation of Macbeth to kill the king. Eventually, she kills herself and leaves Macbeth grieving over the loss.
The army of Macduff and Malcolm comes to the castle. The prophecy makes Macbeth think he is invincible, but he is informed that they're approaching with boughs made from the wood of Birnam and Macduff was born not through woman, but C-section, invalidating the prediction. Macduff beheads Macbeth and the crown is given to Malcolm.