"But not us! An' why? Because... because I got you to look after me, and you got me to look after you, that's why."
"Guys like us, that work on ranches, are the loneliest guys in the world."
"The old man slowly came into the room. He had his broom in his hand. And at his heels there walked a dragfooted sheep dog, gray of muzzle, and with pale, blind eyes."
"Say, what the hell you doin' listenin'?"
"I ain't got no people," George said. "I seen the guys that go around on the ranches alone. That ain't no good."
"They get so they don't want to talk to nobody."
This quote specifically states that ranchers, like George and Lennie are lonely people just because of what they do for work. As a migrant worker you normally do not travel with someone else like George and Lennie, so therefore they realize that they are lucky to have someone to travel and do one of the loneliest jobs with.
"I tell ya a guy get too lonely an' he gets sick."
Candy seems like the type of character that is lonely based on the fact that the dog who is old, blind, pale, and right on his heels. Also this leads the reader to believe that this dog is Candy's closest friend on the ranch because Candy chooses to let the dog be with and follow him with all of his flaws.
"I get lonely," she said. "You can talk to people, but I can't talk to nobody but Curley. Else he gets mad. How'd you like not to talk to anybody."
This conversation between George and Slim shows that men who live on a ranch are lonely and they do not want to talk to people anymore because they are alone so much. Also these ranchers do not become the nicest people and have no desire to be with others and have fun with the men on any ranch they work at.
"Because I got you an' -"
This is the first time we are hearing true emotion come from Crooks and it is the feeling of loneliness on the ranch which is not uncommon. The feeling of being alone is different for Crooks compared to the other guys because his skin color dictates where he sleeps, how he is treated, and what kind of labor he has to do on the ranch. Also most of the time Crooks is separated and secluded from the other guys on the ranch which is causing him to get the feeling of loneliness.
This is the first time we learn about how Curley's wife feels and views life on the ranch from a social standpoint. In this statement Curley's wife reveals how lonely she truly is on the ranch and her desire to talk to others. We also start to understand why she is always looking for Curley-she is just trying to talk to others. The only way Curley's wife can do this is by saying she is looking for Curley to the other men.
The impact on this quote said by Lennie and George right before Lennie's death is significant to the ending of the book. This is because it restates that no matter what George and Lennie do or where they go as ranchers they will never be the loneliest guys in the world. Also it leaves a lasting effect on the reader because this is the last time George and Lennie say this to one another.
"An' I got you. We got each other, that's what, that gives a hoot in hell about us," Lennie cried in triumph.