The Columbian Exchange is an exchange between Europeans and The America's for goods and crops, for other goods and crops.
In this picture, you see one of the native americans crying because he is dying of smallpox. This is one of the diseases the Americans brought with them.
Here you can see all of the money the "Mother Kingdom" got from the trade routes of the Colombian Exchange.
Yes, I just need you to bring me three slaves...
Here, you can see a Native American and an American discussing the exchange of things for another thing.
So, if I give you three of my people, you'll give me long lasting potatoes?
As the result of the Colombian Exchange, we see that the Native American population decreased, though the prosperity of itself did not. In the America's, it caused much grief, though it helped us in the long run.