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When the Europeans first arrived the Native Americans were intrigued and fascinated by them. They showed them new foods, until the Natives started to die off
The Native Americans weren't immune to the same things as the Europeans were. They didn't have domesticated animals which meant they weren't immune to the animals and the bacteria they carried.
This ended up affecting a huge portion of the native population. Since there were no vaccines or medicine they ended up dying of diseases like small pox, and measles.
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