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In cold climates your body temperature will plummet
Your hypothalamus will sense that your cold and will send signals to your body to start shivering to warm itself up
In hot climates your body temperature will skyrocket
Your hypothalamus will send signals to your body that you are too hot and your skin will begin to sweat which will cool you down as it evaporates
Thermoregulation lowers your core body temperature at night when your going to bed and increases it in the morning when you wake up
Opioids like fentanyl, can lower your bod temperature and even cause hypothermia by disturbing the balance of thermoregulatory neurotransmitters