Today we will explain and present the Tumor Suppress Gene and how cancer develops
Tumor Suppressor Gene
When the tumor suppressor gene is mutated, it results in a loss or reduction in their function and liberates the cell from growth constraints and contributes to malignant transformation.
Tumor suppressor genes regulate cell division and replication. It can slow down cell division, repair damaged DNA, and take part in a process called apoptosis or programmed cell death.
In the G2 phase, the cell continues to grow and the cell makes enough organelles and cytoplasm to divide.
In the S phase, the genetic material is copied, allowing there to be enough DNA to be split into two daughter cells
The cell cycle is an ordered sequence of events that occur in a cell in preparation for cell division. The cell cycle consists of four stages: G1, S, G2, and M. In the G1 phase, the cell carries out normal activities. The cell also makes new proteins and organelles as well as grow larger.
The Tumor suppressor cell cycle undergoes with the regular cell cycle, but there is a tumor protein that is added in the genes of the cell.
This tumor protein is also known as p53; this p53 can repair and fix any damage genes.
In the M phase of cell division, mitosis and cytokinesis occur, dividing the cell's copied DNA and cytoplasm to make two new cells.
P53 can be also mutated by not being able to fix the damaged genes and perform apoptosis. If the p53 is mutated in a cell and continues to copy itself, then this will cause the appearance of cancer.
Old cells don’t die off and grow uncontrollably, creating more abnormal cells.
These cells can form a mass of tissue known as a tumor. Cancer cells can then break off of the tumor, travel through the blood or lymph system, and exit the vessels and create more tumors.
Cancer is the uncontrolled growth of abnormal cells in the human body. It is developed when the body’s normal control mechanism stops working as well as accumulated damage to genes.