Philosophiæ Naturalis Principia Mathematica Published by Isaac Newton - July 5, 1687
Andreas Vesalius publish his book - 1543
De Humani Corporis Fabrica
Smallpox vaccine first tested - 1796
Isaac Newton published his book on July 5, 1687. This book is about the three laws of motion, which is one of his big works. The three law was influenced by the three laws of planetary motion of Kepler. Isaac Newton also worked on other things like gravity.
Before Andreas Vesalius finding of the human body was base on a monkey, when he did the dissection and he wrote a book and publish it in 1543
Edward Jenner develops a vaccine for smallpox since smallpox was a big problem. It's called the hand to hand technic, its where he takes a dead skin cell from someone with smallpox and put it in a healthy person. He tested it for the first time in 1796 on a young boy.