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Dave has taken a holiday to Africa not knowing about the types of endemic diseases that he can encounter during his trip. He doesn't notice that there is an infected Tsetse Fly in his surrondings
The Tsetse Fly bites Dave on the arm and injects him with a parasite called 'Trypanosoma brucei'.
The skin tissue is injected with the parasite and then it enters the lymphatic system and passes into the bloodstream. Inside the host, the parasites transform into bloodstream trypomastigotes, are carried to other sites throughout the body, reach other blood fluids (e.g., lymph, spinal fluid), and continue the replication by binary fission. As 1-3 weeks pass, Dave gets a red bump at the sit of injection
Daves immune system uses innate immunity (includes physical barriers such as skin, chemicals in the blood, and immune system cells) to attack the foreign cells in the body as the first line of defence
The trypomastigotes causes the lymph nodes to swell up after Daves body attempts its second line of defense where it uses 'phagocytosis' to try and eliminate the parasite, but it doesn't work.
Dave starts to feel the symptoms of African Sleeping Disease. The swollen lymph nodes causes headaches, fatigue as well as weakness. Now Dave begins to sleep long hours of the day
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