My name is Helicase, and I'm unzipping and unwinding this DNA double helix starting at the replication origin.
Oh I see, you're making a replication fork! I'm DNA Polymerase by the way. Do you need any help?
That would be great actually! Can you help replicate each strand of DNA by pairing adenine with thymine and guanine with cytosine?
You mean complementary base pairing? Sure!
DNA Polymerase got to work, and added all of the nucleotides to the leading strand.
But there was a big problem.
The DNA strands are antiparallel, so I can't add nucleotides to the lagging strand because I can only synthesize strands in the 5' to 3' direction, and the lagging strand is in the 3' to 5' direction!
My name is Primase, and I can add RNA primers to the lagging strand so that you can synthesize it.
I can help!
Really?! Who are you and how can you help?
Thanks a lot!
They worked together to synthesize the lagging strand. Primase added primers to sections of the strand, and then DNA Polymerase added nucleotides.