AP Bio DNA Replication Comic

AP Bio DNA Replication Comic
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  • Hey, what's your name? And what are you doing?
  • My name is Helicase, and I'm unzipping and unwinding this DNA double helix starting at the replication origin.
  • Oh I see, you're making a replication fork! I'm DNA Polymerase by the way. Do you need any help?
  • That would be great actually! Can you help replicate each strand of DNA by pairing adenine with thymine and guanine with cytosine?
  • You mean complementary base pairing? Sure!
  • DNA Polymerase got to work, and added all of the nucleotides to the leading strand.
  • But there was a big problem.
  • The DNA strands are antiparallel, so I can't add nucleotides to the lagging strand because I can only synthesize strands in the 5' to 3' direction, and the lagging strand is in the 3' to 5' direction! 
  • My name is Primase, and I can add RNA primers to the lagging strand so that you can synthesize it.
  • I can help!
  • Really?! Who are you and how can you help?
  • Thanks a lot!
  • They worked together to synthesize the lagging strand. Primase added primers to sections of the strand, and then DNA Polymerase added nucleotides.
  • Primer
  • Lagging Strand of DNA
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