Like most drugs they are grown by farmers who are usually controlled by cartels and other drug organizations in many latin American countires. Then they are harvested to make a profit and transported to other facilities.
Most drugs in there natural form must be made into the buyable product such as cocaine.
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Once it is made and stored in a warehouse they prepare tons of cargo to be smuggled all over the world.
Drugs are smuggled all over by truck shipments and even as cargo on ships. There are many ways to sneak them past the borders and thousands of operations have been caught by the US alone.
Once in the US it is sold an distributed for millions of dollars. Other drug orginizations also take part by controlling there own local territories to buy and sell drugs.
From one end of the world to the other these drugs are smuggled through a very dangerous and sometimes violent processes to be sold to young and old adults that end up addicted demanding more. And drug traffickers will continue to supply.