Macbeth realize that killing Duncan was going too far so he started to feel guilty and got arrested by the police.
After murdering Duncan Macbeth feels guilty about the crime all because he wanted to be king and for his deed he went to jail.
Lady Macbeth's Anxiety
Macbeth and Banquo are sitting in the prison cell finding a way to escape which Macbeth is working on a plan along with the witches without Banquo
While Banquo was asleep Macbeth met the witches and they let him know about the 3 prophecies which was to Beware Macduff, None of women born shall harm Macbeth and Macbeth shall not be defeated until the woods come to his castle. Also, they were successful on helping Macbeth escape from jail
Lady Macbeth feels extremely guilty about all the crimes committed that she starts to believe that there is blood on her hands. Constantly rubbing her hands and washing them to get rid of the blood which eventually leads her to commit suicide
Macbeth was killed in a battle against Macduff because of all the guilt from killing Banquo and king Duncan and he had to face the consequences of his actions