Unfortunately, ECMO infected Addie with a bacteria called Steno, now accompanying the worsening MRSA infection.
Through natural selection the Steno population became pan-resistant. The antibiotics were no longer effective.
In final desperation, the doctors performed a lung replacement surgery on Addie, curing her of threatening concerns and bacteria.
Usually a bacteria population starts off with some variety. Some have more pores (more susceptible), while some have less (more resistant).
Over time the bacteria becomes more resistant because those who are able to survive the antibiotics and reach the stage of copying more often.
As more resistant bacteria are able to copy, the genes passed down to the future generation are more resistant. Mutations can also occur and are not always good.