The three of us combined make up the amino acid Leu!
Come pair with us we match!
E,P and A
The mRNA leaves the nucleus through a nuclear pore where it can begin translation. The nitrogenous bases are grouped into three letter words known as codons. The genetic code is made up of 64 different codons. Most codons code for a specific amino acid.
Hey, lets bond our amino acids
But there are four special codons! One that codes for START and three that code for STOP. Translation begins with the mRNA strand binding to the small ribosomal sub-unit, this is located up stream of the START codon.Each amino acid is brought to the ribosome by a specific transfer RNA molecule. The type of amino acid is determined by the anticodon sequence of the transfer RNA via complementary base pairing .
My job is done here.
A large ribosomal subunit will now come and attach itself to the small subunit. There are three different regions in the large ribosomal subunit, known as the E,P and A sites.
Sorry guys where at the STOP codon have to hop on at the next one.
Individual amino acids are brought to the mRNA strand by a transfer molecule. A charged transfer RNA molecule binds to the A site and a peptide bond forms between its amino acid and the one attached to the RNA molecule at the P site.
Charged transfer RNA molecule
Now the complex slides down one codon to the right where now the uncharged transfer RNA molecule exits from the E site and the A site is now open to the next transfer RNA molecule.
This process will continue until a STOP codon has been reached. when this occurs a release factor binds to the A site at the stop codon and the polypeptide is released from the transfer RNA.