Pandora, open the box. nothing can be worse than the horrors you have already released.
However, just as she was about to turn the key, she felt a pang of guilt and put the items back where she had found them. After doing this three more times, she knew she had to look inside or she would go completely mad.
Pandora could still hear a voice calling to her from the box, pleading with her to be let out. Epimetheus agreed that nothing inside the box could be worse than the horrors that had already been released and so they opened the lid once more.