When Macbeth holds a dinner, in an empty seat he sees Banquo sitting there, but nobody else can. Guilt and fear overwhelms him and he finds himself trying to find the witches once again.
The weird sisters tell him that he should beware of Macduff, that he will not be killed until Birnam woods moves to Dunsinane castle and that he cannot be killed by a man born of a woman.
When Macduff flees to England, Macbeth has his wife and kids killed following what the witches had told him. It wasn't long before he was happy again, unaware of his wife's slow descent into insanity.
Malcolm and Macduff find out what Macbeth has done and become enraged. The two men plan to attack the castle and kill Macbeth. They set off as soon as possible with their army.
Lady Macbeth finally gives into her insanity driven by guilt and jumps from the highest point of the castle to her death just as Macduff and Malcolms arrive at the castle.
Macduff says he was not born of woman as he was ripped from the womb in a c section. He was not born of woman, and could harm Macbeth as the witches predicted. He kills and beheads Macbeth, placing his head on a stick in victory and crowning Malcolm, the rightful king.