The narrator received a letter from Roderick Usher to come for a little while and alleviate him of his bodily illness. When he arrives, he notices that the house seemed, odd and worn down. There was a crack down the middle of the house that shifted the two halves, and the house's condition seemed to correlate with the condition of Roderick Usher.
Roderick describes the condition of his twin sister Madeline to the narrator. The narrator takes a quick look at his sister and she passes. Roderick mourns and his condition becomes worse.
Roderick decides to bury Madeline inside a vault because he is worried that the doctors that were treating her might dig up her grave to perform biopsy on her corpse. However, when they buried her, the narrator notices that Madeline's cheeks are still flushed.
The narrator finds out that Roderick is a hypochondriac. Roderick's condition worsens and believes that he can hear the souls and spirits of inanimate objects. He claimes that they are speaking and are listening to them.
Roderick requests the narrator to read him a book. As he reads the book, the sounds in the book were heard in real life. from the clawing to the shrieking, all sounds were heard from the two men. The final scene was of a person standing in front of the door. Frantically speaking, Roderick realizes that he had buried his twin sister alive and that she is coming for revenge.
From the door appeared Madeline, scratched and bruised from being inside a coffin for a week. They both scream and Roderick knew he was done for.