Dopamine is a neurotransmitter which causes short term euphoria!
When someone takes nicotine it is released into the Mesolimbic pathway which causes pleasure and reduced stress
When someone takes nicotine it is released into the Mesolimbic pathway which causes pleasure and reduced stress.
Acetylcholine (ACh) is a neurotransmitter. the increase of this causes a decrease in dopamine
The ACh binds to ACh receptors (decreases dopamine). One variation (nAChR) is triggered by both ACh and nicotine
The Nicotine binds to the nAChR receptor causing the receptor to SHUT DOWN. This is called DOWN-REGULATION
The nAChR receptor is no longer inhibiting the release of dopamine so dopamine release increases (sending a signal along the mesolithic pathway to the NAcc. This releases dopamine along the mesocorticol pathway to the PFC.