I feel like the first significant event was the French and Indian war because, the war caused so much damage that colonists started paying taxes. and soon almost everyone started paying taxes as well.
The second most significant event was the Townsend act, the British taxed people for tea, paint, lead, imports of paper, and toke away some freedoms from the people.
The 1st continental congress was the least significant for me. It was when, the 13 colonies collided and created the United States. Plus it has no exciting Intel or important information due to taxes or damage.