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- Wood frogs can produce antifreeze.Wood frogs can survive temperatures as low as 3F and come back to life. Winter is coming and the wood frog prepares for the big freeze. It starts to produce huge amounts of urine, but unlike us it doesn't drain this waste, it stores it in its blood.
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- As The first ice crystal creep over the frog's skin, an incredible transformation begins. The water in the frog's blood starts to freeze. The ice sucks the precious water out of the frog's cells. To prevent full scale dehydration, the liver begins to make large amounts of glucose. As the sugar mixes with the urine in the blood, it creates homemade antifreeze
- This concoction packs into frog cells propping them up. The antifreeze prevents too much water being drawn out of the cells by the ice outside-if they lose more than 60% of their water, the process becomes irreversible. The Cells will crumple and die from frostbite. The frog's antifreeze keeps him alive.
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- The wood frog enters a state of suspended animation-its internal organs and metabolic activity grind to a near halt. The lungs stop working, and the heart eventually stops beating. The wood frog can survive for months with an incredible 2/3 of their body completely frozen-to the point where they are essential frogcicles. After a grueling 8 months, spring arrives, the temperatures warm, and the ice starts to melt.
- Hidden within his frozen tomb, the wood frog also begins to thaw. Water slowly flows back into cell, they rehydrate and return to their original shape. Withing 30 minutes, the heart restarts and the blood begins to flow. The wood frog comes back to life. After two days, the frog heads out to look for some food, a mate and a much awaited pee.
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