CDC Museum of ScienceWhere the magic of the human body can be explored!
First Line of Defense
That's right! The first line of defense gets so many of those nasty viruses and bacteria before they can do any harm to you. It's called a nonspecific immune response!
TearsSalivaMucous membranes and ciliaStomach acidsSkin
The Second Line of Defense
The inflammatory response is another type of nonspecific immune response. This is when your body may try to burn off the bacteria. You could get a fever or start too sweat to release the bacteria to the outside of your body.
Phagocyte
"Welcome! Welcome to the CDC Museum of Science! Today we are going to explore the wonders of the immune system and its lines of defense. There are three lines of defense. Can anyone tell me about the first?"
The Second Line of Defense cont.
Natural Killer Cell
Protective Protein
"Skin is so important with keeping harmful bacteria and viruses out of the body. The saliva in your mouth has chemicals that help break down bacteria. Mucous membranes capture bacteria that bumps into it in the back of the throat and cilia help move the bacteria up our throat until we cough it out. Stomach acids have a high concentration of acids that will break down bacteria. Tears help with moving the bacteria out of the body and expelling it."
The Third Line of Defense
Y
"The second line of defense gets a little bit more complicated. Here we have some white blood cells as well. These are called phagocytes or leukocytes. They are responsible for eating foreign particles for eating foreign particles or dead body cells by engulfing them. Once it is engulfed, the phagocyte breaks the foreign particle organelles lysosomes down."
The End
CDC Museum of Science
"Next up is the interferon. These little buggers are viruses. They enter body cells and hijack them. They turn them into a viruses making cell factory until the cell bursts from how many viruses are in there! Then the new viruses go and infect even more cells. The protective proteins directly attack the pathogen or they prevent them from reproducing."
A natural killer cell is so cool! Their job is to find infected cells and inject them with enzymes that cause the cell to die. So how do our own cells not attack each other? We have these really cool proteins#160;on our cells that mark the cell as a "self" cell. These proteins let the natural killer cells know that they are part of us and shouldn't be killed. Pretty cool right?
Interferon
"The third line of defense is a specific immune response. There are a few different parts starting with B cells. B cells are made in the bone marrow, reside in the lymph nodes and spleen, and circulate in the blood and lymph tissues. Activated B cells go through mitosis and clone themselves into plasma cells which create antibodies that can combine with and neutralize a particular antigen."
T cells are created in the bone marrow and mature in the thymus gland. T cells are a little bit different then B cells in the way that they cannot recognize and antigen without an antigen-presenting cell. They help rid of viruses and cancer cells. T cells use the APC to help determine a specific receptor. The T cells make either killer cells or helper T cells to quickly get rid of the antigen. Helper T cells secrete cytokines, enzyme chemicals, that enhance the response of all of the immune cells
B Cell
T Cell
"Well folks, that's it! I thank you for coming and I hope you have enjoyed your time here today. I hope you have learned a few more things about the immune system and its lines of defense from specific to non-specific immune responses! Have a wonderful day!"
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