Lennie is a huge man with large, pale eyes, with wide sloping shoulders, and he walks heavily, dragging his feet a little. Though Lennie is not like any ordinary person. You can determine this in the text by the quote used in the book; "He walked heavily, dragging his feet a little, the way a bear drags his paws. His arms did not swing at his sides, but hung loosely," Already we can sense that he is not normal.
George Milton Small & quick. Strong hands and a thin, bony nose. Leader. Looks after Lennie. George's behaviour is motivated by the desire to protect Lennie and, eventually, deliver them both to the farm of their dreams. Though he is a seemingly harsh man, he cares about Lennie. After being run out of the town of Weed, they prepare to go work at a ranch. George says "I will give him the ranch tickets, but you aint gonna say a word. You jus' stand there and don't say nothing. Despite being initially angry at Lennie for forgetting, he is sure, he is sure to praise him when he does right.
Candy is "a tall, stoop-shouldered old man. He was dressed in blue jeans and carried a big push-broom in his left hand." His right hand is simply a stump because he lost his hand in a ranch accident. Like Candy's dog, Lennie depends on George to take care of him and show him what to do. "A guy on a ranch don't never listen nor he don't ask no questions."Candy gives us a pretty good definition of an isolated person: someone who doesn't ask questions and someone who doesn't listen—in other words, not much of a conversationalist. We're getting the feeling that, for Steinbeck, isolation is mostly about silences which makes friendship mostly about conversation.
Curley. The son of the ranch owner, Curley is a "thin young man with a brown face, with brown eyes and a head of tightly curled hair." He is a small man who likes to pick fights with big men. George's take on Curley is that fighting big men makes Curley feel more macho and controlling. " \the son-of-a-bitch myself." "the guts" Curley speaking about Lennie just after he killed Curley's wife in chapter 5: "I'll kill, I'll shoot 'I'm in." We can get the sense of his personality after reading this quote from him.