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- Let's meet up again tomorrow?
- Sure!!
- That talk was interesting. We can start our assignment now with all the information that we have gained.
- That is all for today. Thank you so much for joining and I hope everyone gained something from this
- The pathogenesis of human Plasmodium falciparum infection is a complex interplay of parasite-induced RBC alterations and microcirculatory abnormalities, accompanied by local and systemic immune reactions, resulting in multiple clinical forms of variable severity.
- RBC infected with early parasite stages (rings) have minor adhesion and/or deformability changes and can circulate, whereas late parasite stages, known as trophozoites and schizonts (mature forms), have significant adhesion/deformability changes that favour their sequestration in small vessels and prevent circulation in the peripheral blood. The adhesion of mature forms to endothelial cells, blood cells, platelets, and uninfected RBCs causes sequestration (uRBCs). Multiple host receptors that parasite adhesins identify orchestrate these interactions.
- For any parasite that is sensitive to chloroquine, it is the chosen treatment. However, parasites have developed resistance to chloroquine in many regions of the world, making the medicine ineffective. ACT is a combination of two or more medications that function in distinct ways against the malaria parasite. Chloroquine-resistant malaria is frequently treated with this drug. Artemether-lumefantrine (Coartem) and artesunate-mefloquine are two examples.
- Plasmodium falciparum is the most common type of malaria that produces severe and life-threatening illness. This parasite is widespread in several African countries south of the Sahara desert. People who are frequently bitten by mosquitoes carrying Plasmodium falciparum are at the greatest risk of contracting malaria.
- What is the most common malaria parasite?
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