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- Stephen Altschul, received a doctorate in mathematics from MIT in 1987.
- Today my research focuses on the development of algorithms and measures for the comparison and analysis of DNA and protein molecules.
- I helped develop methods for estimating statistical parameters for gapped alignments, as well as the statistical theory for ungapped local alignments and for the assessment of multiple distinct alignments.
- the MACAW and Gibbs sampling programs for local multiple alignment,
- I also helped develop the Multiple Sequence Alignment (MSA) program for global multiple sequence alignment,
- and the Basic Local Alignment Search Tool (BLAST) suite of programs for database similarity search.
- Aside from just focusing on algorithms and such, my research also focuses on the construction of appropriate measures for sequence comparison.
- Meaning the development of sequences weighting methods, the description of an information theoretic perspective on substitution matrices, the development of gap costs for pairwise and multiple sequence alignment, and methods for the compositional scaling and adjustment of substitution matrices.
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