Fatty acids
Storyboard Text
- What is the fatty acid ß_oxidation?
- It is break down of fatty acid to produce energy.It occurs when person at fasting state.
- I know that Fatty acid is stored in adipose tissue as TAG,but do you know how does mobilization of stored fat occure?
- Enzyme called hormone-sensitive lipase "HSL" breaks down TAG into free fatty acid and glycerol.
- Short or medium-chain fatty acid (C<12)can enter into inner mitochondia to be oxidised and give energy but long chain fatty acid (C>12)can't enter.
- Let me till you how Long chain fatty acids undego ß-oxidation.
- First, activation of free fatty acid by interaction with Coenzyme A in cytosol.
- I am inactive fatty acid.
- Hi,i am active fatty acyl-COA.
- Second,translocation of fatty acyl_COA to mitochondria by carnitine shuttle.it is very important and rate-limiting step
- I am going to inner mitochondria.
- And finally ß_oxidation of fatty acyl_COA takes place,and it includes 4 reaction which are (oxidation, hydration, another oxidation,and finally thiolytic cleavage).
- I am in mitochondria and ready to be oxidised and giving energy.
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